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DeCS
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Descriptor English:
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Proto-Oncogene Proteins c-bcr
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Descriptor Spanish:
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Proteínas Proto-Oncogénicas c-bcr
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Descriptor Portuguese:
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Proteínas Proto-Oncogênicas c-bcr
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Synonyms English:
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Breakpoint Cluster Region Protein
Proto Oncogene Protein bcr
Proto Oncogene Protein c bcr
Proto Oncogene Proteins c bcr
Proto-Oncogene Protein bcr
Proto-Oncogene Protein c-bcr
Proto-Oncogene Proteins, bcr
Proto-Oncogene Proteins, c-bcr
bcr Proto Oncogene Proteins
bcr Proto-Oncogene Proteins
c bcr Proteins
c bcr Proto Oncogene Proteins
c-bcr Proteins
c-bcr Proto-Oncogene Proteins
c-bcr, Proto-Oncogene Protein
c-bcr, Proto-Oncogene Proteins
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Tree Number:
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D08.811.913.696.620.682.700.759
D12.644.360.325.300.099.500
D12.776.476.325.300.099.500
D12.776.624.664.700.171
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Definition English:
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A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients. |
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History Note English:
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2006(1988)
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Allowable Qualifiers English:
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Record Number:
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50725
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Unique Identifier:
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D051562
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Occurrence in VHL:
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Similar:
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DeCS
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